Manganese has some control over the liver's ability to break down estrogen, so too much Vitamin C can affect the length of the menstrual cycle and worsen low estrogenic-types of PMS. On the other hand, congestive liver disease, resulting in higher estrogen levels, will benefit from higher doses of Vitamin C by reducing the symptoms of high estrogenic-types of PMS, while at the same time reducing the risk to develop estrogen sensitive types of cancer or fibroid tumors that may develop as a result of a lifelong higher mean average level of estrogen... Full Text